A primary transcript is an RNA molecule that has not yet undergone any modification after its synthesis such as methylation, or the addition of a Poly-A tail. For example, a precursor messenger RNA (pre-mRNA) is a primary transcript that becomes a messenger RNA (mRNA) after processing, and a primary microRNA (pri-miRNA) precursor becomes a microRNA (miRNA) after processing.
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“Without the Constitution and the Union, we could not have attained the result; but even these, are not the primary cause of our great prosperity. There is something back of these, entwining itself more closely about the human heart. That something, is the principle of “Liberty to all”Mthe principle that clears the path for all—gives hope to all—and, by consequence, enterprize [sic], and industry to all.”
—Abraham Lincoln (1809–1865)