Primary biliary cirrhosis, often abbreviated PBC, is an autoimmune disease of the liver marked by the slow progressive destruction of the small bile ducts (bile canaliculi) within the liver. When these ducts are damaged, bile builds up in the liver (cholestasis) and over time damages the tissue. This can lead to scarring, fibrosis and cirrhosis. It was previously thought to be a rare disease, but more recent studies have shown that it may affect up to 1 in 3–4,000 people; the sex ratio is at least 9:1 (female to male).
Read more about Primary Biliary Cirrhosis: Signs and Symptoms, Diagnosis, Etiology, Therapy, Epidemiology, Prognosis, History, Additional Images
Famous quotes containing the words primary and/or biliary:
“If the accumulated wealth of the past generations is thus tainted,—no matter how much of it is offered to us,—we must begin to consider if it were not the nobler part to renounce it, and to put ourselves in primary relations with the soil and nature, and abstaining from whatever is dishonest and unclean, to take each of us bravely his part, with his own hands, in the manual labor of the world.”
—Ralph Waldo Emerson (1803–1882)
“I knew a witty physician who found theology in the biliary duct, and used to affirm that if there was a disease in the liver, the man became a Calvinist, and if that organ was sound, he became a Unitarian.”
—Ralph Waldo Emerson (1803–1882)