Meier-Gorlin Syndrome
Defects in components of the eukaryotic replication complex are known to cause Meier-Gorlin syndrome, which is characterized by absent or hypoplastic patellae, small ears, impaired pre- and post-natal growth, and microcephaly. Known mutations are in the ORC1, ORC4, ORC6, CDT1, and CDC6 genes. The disease phenotype probably originates from reduced ability of cells to proliferate, reduced cell number, and general growth failure.
Read more about this topic: Pre-replication Complex
Famous quotes containing the word syndrome:
“Women are taught that their main goal in life is to serve othersfirst men, and later, children. This prescription leads to enormous problems, for it is supposed to be carried out as if women did not have needs of their own, as if one could serve others without simultaneously attending to ones own interests and desires. Carried to its perfection, it produces the martyr syndrome or the smothering wife and mother.”
—Jean Baker Miller (20th century)