Mechanism of Action
In general, potassium binders are artificial resins that exchange bound cations (Ca2+ or Na+) for potassium ions in the large intestine. After exchange, the released cation and potassium adhering to the resin are excreted with the faeces. This mechanism prevents intestinal absorption of alimentary potassium ions and thereby reduces serum potassium levels. There are two major classes of binders, differentiated by the cation attached to the resin in the original condition. Calcium resins release calcium ions in exchange for potassium ions, whereas sodium resins release sodium.
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