Structure
The 3D structure of several PH domains has been determined. All known cases have a common structure consisting of two perpendicular anti-parallel beta sheets, followed by a C-terminal amphipathic helix. The loops connecting the beta-strands differ greatly in length, making the PH domain relatively difficult to detect while providing the source of the domain's specificity. The only conserved residue among PH domains is a single tryptophan located within the alpha helix that serves to nucleate the core of the domain.
Read more about this topic: Pleckstrin Homology Domain
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“It is difficult even to choose the adjective
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The greenhouse never so badly needed paint.”
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—Sarah Patton Boyle, U.S. civil rights activist and author. The Desegregated Heart, part 2, ch. 2 (1962)
“Communism is a proposition to structure the world more reasonably, a proposition for changing the world. As such, we have to analyze it and, if we deem it reasonable, act upon it.”
—Friedrich Dürrenmatt (1921–1990)