Interactions of The Platelet Surface Glycoproteins
The binding of von Willebrand factor (vWF) results in conformational changes within the GPIb-IX-V complex. In consequence, this complex activates GPIIb / IIIa membrane glycoproteins allowing them to bind fibrinogen. Fibrinogen molecules then interconnect the platelets serving as the basis for platelet aggregation. In the absence of fibrinogen, the platelets are joined by vWF due to its ability to bind the activated GPIIb / IIIa complex.
Read more about this topic: Platelet Membrane Glycoprotein
Famous quotes containing the words interactions and/or surface:
“In our interactions with people, a benevolent hypocrisy is frequently required—acting as though we do not see through the motives of their actions.”
—Friedrich Nietzsche (1844–1900)
“See how peaceful it is here. The sea is everything. An immense reservoir of nature where I roam at will.... Think of it. On the surface there is hunger and fear. Men still exercise unjust laws. They fight, tear one another to pieces. A mere few feet beneath the waves their reign ceases, their evil drowns. Here on the ocean floor is the only independence. Here I am free.”
—Earl Felton, and Richard Fleischer. Captain Nemo (James Mason)