Plasminogen Activator

A plasminogen activator is a serine protease which converts plasminogen to plasmin, thus promoting fibrinolysis.

Types include:

  • Tissue plasminogen activator
  • Urokinase

It is inhibited by plasminogen activator inhibitor-1 and plasminogen activator inhibitor-2.

Endopeptidases: serine proteases/serine endopeptidases (EC 3.4.21)
Digestive enzymes
  • Enteropeptidase
  • Trypsin
  • Chymotrypsin
  • Elastase
    • Neutrophil
    • Pancreatic
Coagulation
  • factors: Thrombin
  • Factor VIIa
  • Factor IXa
  • Factor Xa
  • Factor XIa
  • Factor XIIa
  • Kallikrein
    • PSA
    • KLK1
    • KLK2
    • KLK3
    • KLK4
    • KLK5
    • KLK6
    • KLK7
    • KLK8
    • KLK9
    • KLK10
    • KLK11
    • KLK12
    • KLK13
    • KLK14
    • KLK15
  • fibrinolysis: Plasmin
  • Plasminogen activator
    • Tissue plasminogen activator
    • Urinary plasminogen activator
Complement system
  • Factor B
  • Factor D
  • Factor I
  • MASP
    • MASP1
    • MASP2
  • C3-convertase
Other immune system
  • Chymase
  • Granzyme
  • Tryptase
  • Proteinase 3/Myeloblastin
Venombin
  • Ancrod
  • Batroxobin
Other
  • Acrosin
  • Prolyl endopeptidase
  • Pronase
  • Proprotein convertases
    • 1
    • 2
  • Reelin
  • Subtilisin/Furin
  • Streptokinase
  • S1P
  • Cathepsin
    • A
    • G
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Plasminogen

PDB rendering based on 4dur.
Available structures
PDB Ortholog search: PDBe, RCSB
List of PDB id codes

1B2I, 1BML, 1BUI, 1CEA, 1CEB, 1DDJ, 1HPJ, 1HPK, 1I5K, 1KI0, 1KRN, 1L4D, 1L4Z, 1PK4, 1PKR, 1PMK, 1QRZ, 1RJX, 2DOH, 2DOI, 2KNF, 2L0S, 2PK4, 4A5T, 4DCB, 4DUR, 4DUU, 5HPG
Identifiers
Symbols PLG; DKFZp779M0222
External IDs OMIM: 173350 MGI: 97620 HomoloGene: 55452 ChEMBL: 1801 GeneCards: PLG Gene
EC number 3.4.21.7
Gene Ontology
Molecular function • serine-type endopeptidase activity
• protein binding
• protein domain specific binding
• apolipoprotein binding
• cell surface binding
Cellular component • extracellular region
• extracellular space
• plasma membrane
• platelet alpha granule lumen
• extrinsic to external side of plasma membrane
Biological process • platelet degranulation
• proteolysis
• blood coagulation
• negative regulation of cell proliferation
• negative regulation of cell-substrate adhesion
• extracellular matrix disassembly
• platelet activation
• extracellular matrix organization
• fibrinolysis
• tissue remodeling
• negative regulation of fibrinolysis
• positive regulation of fibrinolysis
• negative regulation of cell-cell adhesion mediated by cadherin
Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5340 18815
Ensembl ENSG00000122194 ENSMUSG00000059481
UniProt P00747 P20918
RefSeq (mRNA) NM_000301.3 NM_008877.3
RefSeq (protein) NP_000292.1 NP_032903.3
Location (UCSC) Chr 6:
161.12 – 161.17 Mb		 Chr 17:
12.38 – 12.42 Mb
PubMed search
Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
Antiplatelet drugs
Glycoprotein IIb/IIIa inhibitors
  • Abciximab
  • Eptifibatide
  • Tirofiban
ADP receptor/P2Y12 inhibitors
  • thienopyridines
    • Clopidogrel
    • Prasugrel
    • Ticlopidine
  • nucleotide/nucleoside analogs
    • Cangrelor
    • Elinogrel
    • Ticagrelor
Prostaglandin analogue (PGI2)
  • Beraprost
  • Prostacyclin
  • Iloprost
  • Treprostinil
COX inhibitors
  • Acetylsalicylic acid/Aspirin#
  • Aloxiprin
  • Carbasalate calcium
  • Indobufen
  • Triflusal
Thromboxane inhibitors
  • thromboxane synthase inhibitors
    • Dipyridamole
    • Picotamide
  • receptor antagonist
    • Terutroban†
Phosphodiesterase inhibitors
  • Cilostazol
  • Dipyridamole
  • Triflusal
Other
  • Cloricromen
  • Ditazole
Anticoagulants
Vitamin K antagonists
(inhibit II, VII, IX, X)
  • coumarins: Acenocoumarol
  • Coumatetralyl
  • Dicoumarol
  • Ethyl biscoumacetate
  • Phenprocoumon
  • Warfarin#
  • 1,3-Indandiones: Clorindione
  • Diphenadione
  • Phenindione
  • other: Tioclomarol
Factor Xa inhibitors
(with some II inhibition)
Heparin group/
glycosaminoglycans/
(bind antithrombin)
  • low-molecular-weight heparin
    • Bemiparin
    • Certoparin
    • Dalteparin
    • Enoxaparin
    • Nadroparin
    • Parnaparin
    • Reviparin
    • Tinzaparin
  • oligosaccharides
    • Fondaparinux
    • Idraparinux
  • heparinoid
    • Danaparoid
    • Sulodexide
    • Dermatan sulfate
Direct Xa inhibitors
  • xabans
    • Apixaban
    • Betrixaban
  • Edoxaban
    • Otamixaban
    • Rivaroxaban
Direct thrombin (II) inhibitors
  • bivalent: Hirudin
    • Bivalirudin
    • Lepirudin
    • Desirudin
  • univalent: Argatroban
  • Dabigatran
  • Melagatran‡
  • Ximelagatran‡
Other
  • REG1
  • Defibrotide
  • Ramatroban
  • Antithrombin III
  • Protein C
    • Drotrecogin alfa
Thrombolytic drugs/
fibrinolytics
  • plasminogen activators: r-tPA
    • Alteplase
    • Reteplase
    • Tenecteplase
  • UPA
    • Urokinase
    • Saruplase
  • Streptokinase#
  • Anistreplase
  • Monteplase
  • other serine endopeptidases: Ancrod
  • Fibrinolysin
  • Brinase
Non-medicinal
  • Citrate
  • EDTA
  • Oxalate
  • #WHO-EM
  • ‡Withdrawn from market
  • Clinical trials:
    • †Phase III
    • §Never to phase III

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns