PKS may refer to:
- Phi Kappa Sigma International Fraternity
- Państwowa Komunikacja Samochodowa, Polish state bus transport organization
- Prosperous Justice Party, a political party in Indonesia
- Polyketide synthase, a large enzyme complex responsible for polyketide biosynthesis
- Pine Knoll Shores, North Carolina - a beach town in the U.S.A. state of North Carolina
- Parkes Observatory - Radio telescope observatory, 20 kilometres north of the town of Parkes, New South Wales