Piola may refer to:
- Domenico Piola (1624–1703), an Italian artist from Genova
- Gabrio Piola (1794–1850), an Italian physicist, after whom a piazza in Milan, and subsequently its metro station, were named
- Silvio Piola (1913–1996), an Italian footballer
- Valle Piola, a deserted village located in the commune of Torricella Sicura in the Province of Teramo in the Abruzzo Region of Italy
- The Uzbek name for a piala, a type of bowl for drinking tea from.