Lethal White Syndrome
As noted in the description of patterns, above, the frame gene is associated with a condition called lethal white syndrome or "lethal white overo". However, of the overo family of patterns, only frame is associated with lethal white. Also, some horses that do not visually appear to be frame patterned still do carry the gene. However, if a foal is born homozygous for the gene, it dies shortly after birth. This gene can be detected by DNA testing, and breeders can now avoid breeding two carrier horses to one another.
Read more about this topic: Pinto Horse, Controversies
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