Signs and Symptoms
The symptoms of Pick's disease include difficulty in speech and thinking, behavioral changes, impaired regulation of social conduct (e.g. breaches of etiquette, tactlessness, dis-inhibition), passivity, inertia, over-activity, pacing and wandering. The changes in personality allow doctors to distinguish between Pick's disease and Alzheimer's disease. Pick's disease is one of the causes of the clinical syndrome of frontotemporal lobar degeneration which has three subtypes. Pick's disease pathology is associated more with the frontotemporal dementia and progressive nonfluent aphasia subtypes than the semantic dementia subtype.
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