Picacho may refer to:
- Mexico
- Villa de Hidalgo, San Luis Potosí
- Picacho del Diablo, Baja California
- Panama
- Picacho Mountain
- United States
- Picacho, California
- Picacho State Recreation Area
- Little Picacho Wilderness, California
- Picacho, Arizona
- Picacho Peak State Park, Arizona
- Battle of Picacho Pass
- Venezuela
- Picacho de El Volcán, Miranda
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