Domain Structure
In terms of domain organization, all family members possess homologous X and Y catalytic domains in the form of a distorted Triose Phosphate Isomerase (TIM) barrel with a highly disordered, charged, and flexible intervening linker region. Likewise, all isoforms possess four EF hand domains, and a single C2 domain that flank the X and Y catalytic core. An N-terminal PH domain is present in every family except for the sperm-specific ζ isoform.
SH2 (phosphotyrosine binding) and SH3 (proline-rich-binding) domains are found only in the γ form (specifically within the linker region), and only the ε form contains both guanine nucleotide exchange factor (GEF) and RA (Ras Associating) domains. The β subfamily is distinguished from the others by the presence of a long C-terminal extension immediately downstream of the C2 domain, which is required for activation by Gαq subunits, and which plays a role in plasma membrane binding and nuclear localization.
Read more about this topic: Phosphoinositide Phospholipase C
Famous quotes containing the words domain and/or structure:
“While you are divided from us by geographical lines, which are imaginary, and by a language which is not the same, you have not come to an alien people or land. In the realm of the heart, in the domain of the mind, there are no geographical lines dividing the nations.”
—Anna Howard Shaw (1847–1919)
“Who says that fictions only and false hair
Become a verse? Is there in truth no beauty?
Is all good structure in a winding stair?
May no lines pass, except they do their duty
Not to a true, but painted chair?”
—George Herbert (1593–1633)