Structure Data On The PHD Finger
The NMR structure of the PHD finger from human WSTF (Williams Syndrome Transcription Factor) shows that the conserved cysteines and histidine coordinate two Zn2+ ions. In general, the PHD finger adopts a globular fold, consisting of a two-stranded beta-sheet and an alpha-helix. The region consisting of these secondary structures and the residues involved in coordinating the zinc-ions are very conserved among species. The loop regions I and II are variable and could contribute functional specificity to the different PHD fingers.
Read more about this topic: PHD Finger
Famous quotes containing the words structure, data and/or finger:
“What is the structure of government that will best guard against the precipitate counsels and factious combinations for unjust purposes, without a sacrifice of the fundamental principle of republicanism?”
—James Madison (1751–1836)
“This city is neither a jungle nor the moon.... In long shot: a cosmic smudge, a conglomerate of bleeding energies. Close up, it is a fairly legible printed circuit, a transistorized labyrinth of beastly tracks, a data bank for asthmatic voice-prints.”
—Susan Sontag (b. 1933)
“I asked you to play. If you can’t think of anything better, play a chromatic five finger exercise. But spare me your suburban shopgirl trash.”
—Muriel Box (b. 1905)