Nested DNA Inversion
In this form of phase variation. The promoter region of the genome can move from one copy of a gene to another through homologous recombination. This occurs with Campylobacter fetus surface proteins. The several different surface antigen proteins are all silent apart from one and all share a conserved region at the 5' end. The promoter sequence can then move between these conserved regions and allow expression of a different gene.
Read more about this topic: Phase Variation
Famous quotes containing the words nested and/or dna:
“I was asking for something specific and perfect for my city,
Whereupon lo! upsprang the aboriginal name.
Now I see what there is in a name, a word, liquid, sane, unruly,
musical, self-sufficient,
I see that the word of my city is that word from of old,
Because I see that word nested in nests of water-bays, superb,
Rich, hemmd thick all around with sailships and steamships, an
island sixteen miles long, solid-founded,”
—Walt Whitman (18191892)
“Here [in London, history] ... seemed the very fabric of things, as if the city were a single growth of stone and brick, uncounted strata of message and meaning, age upon age, generated over the centuries to the dictates of some now all-but-unreadable DNA of commerce and empire.”
—William Gibson (b. 1948)