Pestis may refer to:
- a Latin word for the plague, a disease caused by Yersinia pestis, a Gram-negative rod-shaped bacterium species
- Pestiš, a village in the municipality of Prokuplje, Serbia
- Peştiş, a village in Aleşd town, Bihor County, Romania
- Peştiş River (Cerna), a tributary of the Cerna river in Romania
- Peștiș River (Mureș), a tributary of the Mureş River in Romania
- Peştiş River (Topa), a tributary of the Pârâul Morilor in Romania
- Scrutinium Pestis, a 1658 book by Athanasius Kircher