A PEST sequence is a peptide sequence which is rich in proline (P), glutamic acid (E), serine (S), and threonine (T). This sequence is associated with proteins that have a short intracellular half-life; hence, it is hypothesized that the PEST sequence acts as a signal peptide for protein degradation.
The degradation may be mediated possibly via the proteosome or calpain.
Famous quotes containing the words pest and/or sequence:
“The pest of society is egotists. There are dull and bright, sacred and profane, coarse and fine egotists. ‘Tis a disease that, like influenza, falls on all constitutions.”
—Ralph Waldo Emerson (1803–1882)
“Reminiscences, even extensive ones, do not always amount to an autobiography.... For autobiography has to do with time, with sequence and what makes up the continuous flow of life. Here, I am talking of a space, of moments and discontinuities. For even if months and years appear here, it is in the form they have in the moment of recollection. This strange form—it may be called fleeting or eternal—is in neither case the stuff that life is made of.”
—Walter Benjamin (1892–1940)