Nomenclature and Tissue Distribution
| Peroxisome proliferator-activated receptor alpha | |
|---|---|
| Identifiers | |
| Symbol | PPARA |
| Alt. symbols | PPAR |
| Entrez | 5465 |
| HUGO | 9232 |
| OMIM | 170998 |
| RefSeq | NM_001001928 |
| UniProt | Q07869 |
| Other data | |
| Locus | Chr. 22 q12-q13.1 |
| Peroxisome proliferator-activated receptor gamma | |
|---|---|
| Identifiers | |
| Symbol | PPARG |
| Entrez | 5468 |
| HUGO | 9236 |
| OMIM | 601487 |
| RefSeq | NM_005037 |
| UniProt | P37231 |
| Other data | |
| Locus | Chr. 3 p25 |
| Peroxisome proliferator-activated receptor delta | |
|---|---|
| Identifiers | |
| Symbol | PPARD |
| Entrez | 5467 |
| HUGO | 9235 |
| OMIM | 600409 |
| RefSeq | NM_006238 |
| UniProt | Q03181 |
| Other data | |
| Locus | Chr. 6 p21.2 |
Three types of PPARs have been identified: alpha, gamma, and delta (beta):
- α (alpha) - expressed in liver, kidney, heart, muscle, adipose tissue, and others
- β/δ (beta/delta) - expressed in many tissues but markedly in brain, adipose tissue, and skin
- γ (gamma) - although transcribed by the same gene, this PPAR through alternative splicing is expressed in three forms:
- γ1 - expressed in virtually all tissues, including heart, muscle, colon, kidney, pancreas, and spleen
- γ2 - expressed mainly in adipose tissue (30 amino acids longer)
- γ3 - expressed in macrophages, large intestine, white adipose tissue.
Read more about this topic: Peroxisome Proliferator-activated Receptor
Famous quotes containing the words tissue and/or distribution:
“Whether or not his newspaper and a set of senses reduced to five are the main sources of the so-called “real life” of the so- called average man, one thing is fortunately certain: namely, that the average man himself is but a piece of fiction, a tissue of statistics.”
—Vladimir Nabokov (1899–1977)
“Classical and romantic: private language of a family quarrel, a dead dispute over the distribution of emphasis between man and nature.”
—Cyril Connolly (1903–1974)