Related Compounds
Compounds that are structurally related to DTPA are used in medicine, taking advantage of the high affinity of the triaminopentacarboxylate scaffold for metal ions.
- In ibritumomab tiuxetan, the chelator tiuxetan is a modified version of DTPA whose carbon backbone contains an isothiocyanatobenzyl and a methyl group.
- In capromab pendetide and satumomab pendetide, the chelator pendetide (GYK-DTPA) is a modified DTPA containing a peptide linker used to connect the chelate to an antibody.
- Pentetreotide is a modified DTPA attached to a peptide segment.
- DTPA and derivatives are used to chelate gadolinium to form a MRI contrast agent, such as Magnevist.
- Technetium is chelated with DTPA for ventilation perfusion scan (V/Q scan) and renal scan.
Read more about this topic: Pentetic Acid
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