Related Compounds
Compounds that are structurally related to DTPA are used in medicine, taking advantage of the high affinity of the triaminopentacarboxylate scaffold for metal ions.
- In ibritumomab tiuxetan, the chelator tiuxetan is a modified version of DTPA whose carbon backbone contains an isothiocyanatobenzyl and a methyl group.
- In capromab pendetide and satumomab pendetide, the chelator pendetide (GYK-DTPA) is a modified DTPA containing a peptide linker used to connect the chelate to an antibody.
- Pentetreotide is a modified DTPA attached to a peptide segment.
- DTPA and derivatives are used to chelate gadolinium to form a MRI contrast agent, such as Magnevist.
- Technetium is chelated with DTPA for ventilation perfusion scan (V/Q scan) and renal scan.
Read more about this topic: Pentetic Acid
Famous quotes containing the words related and/or compounds:
“Perhaps it is nothingness which is real and our dream which is non-existent, but then we feel think that these musical phrases, and the notions related to the dream, are nothing too. We will die, but our hostages are the divine captives who will follow our chance. And death with them is somewhat less bitter, less inglorious, perhaps less probable.”
—Marcel Proust (1871–1922)
“We can come up with a working definition of life, which is what we did for the Viking mission to Mars. We said we could think in terms of a large molecule made up of carbon compounds that can replicate, or make copies of itself, and metabolize food and energy. So that’s the thought: macrocolecule, metabolism, replication.”
—Cyril Ponnamperuma (b. 1923)