Route Description
PA 99 begins at an intersection with US 6/US 19 near the northern edge of Cambridge Springs. The route heads northwest, crossing Conneauttee Creek at Drakes Mills midway between Cambridge Springs and the Crawford-Erie county line. North of the county line, PA 99 crosses the creek once more and follows the waterway into Edinboro. Within the borough, PA 99 passes by Edinboro University of Pennsylvania south of an intersection with U.S. Route 6N in the center of the borough. The route continues northward, following the eastern edge of Edinboro Lake for a short distance.
Near McKean, PA 99 begins to parallel Interstate 79 as both roadways approach Erie. Midway between McKean and Erie, PA 99 passes over Interstate 90 east of its interchange with I-79. Just south of the city limits in the Millcreek Township community of Kearsarge, PA 99 separates from I-79 and turns east at a T-intersection to access US 19, where PA 99 terminates.
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