PDX may refer to:
- Portland International Airport's IATA code
- Union Station (Portland, Oregon)'s railway code
- Paradox (warez) or PDX, a warez group
- Performance Driving eXperience, a type of event sanctioned by the Sports Car Club of America
- PDX, a line of musical instruments and equipment by Vestax
- Product data eXchange, an XML-based format used in manufacturing