Patrick Murphy may refer to:
- Patrick Murphy (giant) (1834–1862), Irish giant
- Patrick Murphy (Irish politician) (1889–1968), Irish Fianna Fáil politician from Cork
- Patrick Murphy (Medal of Honor) (1823–1896), American Civil War sailor and Medal of Honor recipient
- Patrick Murphy (Pennsylvania politician) (born 1973), U.S. Representative from Pennsylvania from 2007-2011
- Patrick Murphy (Florida politician), member of United States House of Representatives
- Patrick Murphy (softball coach) (born 1965), coach at the University of Alabama
- Patrick Murphy (swimmer) (born 1984), Australian Olympic swimmer of 2008
- Patrick O. Murphy, mayor of Lowell, Massachusetts
- G. Patrick Murphy (born 1948), U.S. federal judge
- Patrick Charles Murphy (1868–1925), Canadian Senator
- Patrick Henry Murphy, member of the Texas Seven, prison escapees 2000–2001
- Patrick V. Murphy (1920–2011), New York City Police Commissioner, 1970–1973
- Patrick J. Murphy (1933-2003), NYPD Chief and First Deputy Commissioner in the 1980s
- Patrick Murphy (pilot), Irish pilot who bombed Naco, Arizona in 1929
- Patrick Murphy (producer), American television producer
- Pat Murphy (rugby union), Australian rugby union player
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