Drug Resistance
Treatment with anti-fungal drugs often results in the appearance of resistant strains of fungi. Various mechanisms leading to resistance have been described. For example, a number of resistant clinical isolates overexpress genes encoding drug efflux pumps. Recent advances in molecular biology have allowed the study of the phenomenon of multi-drug resistance on a genome-wide scale. DNA micro-arrays are being used to study the expression profiling of pathogenic fungi and proteomics is aiding research in the development of resistance to various anti-fungal drugs.
Read more about this topic: Pathogenic Fungi
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—Sun Tzu (6–5th century B.C.)