The Passerini reaction is a chemical reaction involving an isocyanide, an aldehyde (or ketone), and a carboxylic acid to form a α-acyloxy amide.
This organic reaction was discovered by Mario Passerini in 1921 in Florence, Italy. It is the first isocyanide based multi-component reaction developed, and currently plays a central role in combinatorial chemistry.
Recently, Denmark et al. have developed an enantioselective catalyst for aymmetric Passerini reactions.
Read more about Passerini Reaction: Scope
Famous quotes containing the word reaction:
“Children, randomly at first, hit upon something sooner or later that is their mother’s and/or father’s Achilles’ heel, a kind of behavior that especially upsets, offends, irritates or embarrasses them. One parent dislikes name-calling, another teasing...another bathroom jokes. For the parents, this behavior my have ties back to their childhood, many have been something not allowed, forbidden, and when it appears in the child, it causes high-voltage reaction in the parent.”
—Ellen Galinsky (20th century)