The Passerini reaction is a chemical reaction involving an isocyanide, an aldehyde (or ketone), and a carboxylic acid to form a α-acyloxy amide.
This organic reaction was discovered by Mario Passerini in 1921 in Florence, Italy. It is the first isocyanide based multi-component reaction developed, and currently plays a central role in combinatorial chemistry.
Recently, Denmark et al. have developed an enantioselective catalyst for aymmetric Passerini reactions.
Read more about Passerini Reaction: Scope
Famous quotes containing the word reaction:
“Sole and self-commanded works,
Fears not undermining days,
Grows by decays,
And, by the famous might that lurks
In reaction and recoil,
Makes flames to freeze, and ice to boil.”
—Ralph Waldo Emerson (1803–1882)