Parkin (ligase)

Parkin (ligase)

Identifiers Symbols PARK2; AR-JP; LPRS2; PDJ; PRKN External IDs OMIM: 602544 MGI: 1355296 HomoloGene: 3355 GeneCards: PARK2 Gene EC number

Gene Ontology
Molecular function ubiquitin-protein ligase activity
protein binding
zinc ion binding
kinase binding
protein kinase binding
PDZ domain binding
ubiquitin protein ligase binding
chaperone binding
Cellular component nucleus
endoplasmic reticulum
Golgi apparatus
perinuclear region of cytoplasm
Biological process protein polyubiquitination
mitochondrion degradation
negative regulation of protein phosphorylation
ubiquitin-dependent protein catabolic process
protein monoubiquitination
central nervous system development
cell death
regulation of autophagy
negative regulation of actin filament bundle assembly
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of I-kappaB kinase/NF-kappaB cascade
negative regulation of neuron apoptotic process
protein autoubiquitination
negative regulation of cell death
protein K63-linked ubiquitination
aggresome assembly
protein K48-linked ubiquitination
neuron death
negative regulation of release of cytochrome c from mitochondria
regulation of reactive oxygen species metabolic process
Sources: Amigo / QuickGO
RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5071 50873 Ensembl ENSG00000185345 ENSMUSG00000023826 UniProt O60260 Q9WVS6 RefSeq (mRNA) NM_004562.2 NM_016694.3 RefSeq (protein) NP_004553.2 NP_057903.1 Location (UCSC) Chr 6:
161.77 – 163.15 Mb Chr 17:
11.07 – 11.64 Mb PubMed search

Parkin is a protein which in humans is encoded by the PARK2 gene. The precise function of this protein is unknown; however, the protein is a component of a multiprotein E3 ubiquitin ligase complex which in turn is part of the ubiquitin-proteasome system that mediates the targeting of proteins for degradation. Mutations in this gene are known to cause a familial form of Parkinson's disease known as autosomal recessive juvenile Parkinson disease.

How loss of function of the parkin protein leads to dopaminergic cell death in this disease is unclear. The prevailing hypothesis is that parkin helps degrade one or more proteins toxic to dopaminergic neurons. Putative substrates of parkin include synphilin-1, CDC-rel1, cyclin E, p38 tRNA synthase, Pael-R, synaptotagmin XI, sp22 and parkin itself (see also ubiquitin ligase). Additionally, Parkin contains a C-terminal motif that binds PDZ domains. Parkin has been shown to associate in a PDZ dependent manner with the PDZ domain containing proteins CASK and PICK1.

Read more about Parkin (ligase):  Parkinson's Disease, Interactions