Structure Activity Relationships For Parasympathomimetic Drugs
For a cholinergic agent, the following criteria describe the structure activity relationship:
- Ing's Rule of 5: There should be no more than five atoms between the nitrogen and the terminal hydrogen for Muscarinic (or cholinergic) activity.
- molecule must possess a nitrogen atom capable of bearing a positive charge, preferably a quaternary ammonium salt.
- for maximum potency, the size of the alkyl groups substituted on the nitrogen should not exceed the size of a methyl group.
- The molecule should have an oxygen atom, preferably an ester-like oxygen capable of participating in a hydrogen bond.
- There should be a two-carbon unit between the oxygen atom and the nitrogen atom.
Read more about this topic: Parasympathomimetic Drug
Famous quotes containing the words structure, activity and/or drugs:
“Agnosticism is a perfectly respectable and tenable philosophical position; it is not dogmatic and makes no pronouncements about the ultimate truths of the universe. It remains open to evidence and persuasion; lacking faith, it nevertheless does not deride faith. Atheism, on the other hand, is as unyielding and dogmatic about religious belief as true believers are about heathens. It tries to use reason to demolish a structure that is not built upon reason.”
—Sydney J. Harris (1917–1986)
“Who shall set a limit to the influence of a human being? There are men, who, by their sympathetic attractions, carry nations with them, and lead the activity of the human race. And if there be such a tie, that, wherever the mind of man goes, nature will accompany him, perhaps there are men whose magnetisms are of that force to draw material and elemental powers, and, where they appear, immense instrumentalities organize around them.”
—Ralph Waldo Emerson (1803–1882)
“If we became students of Malcolm X, we would not have young black men out there killing each other like they’re killing each other now. Young black men would not be impregnating young black women at the rate going on now. We’d not have the drugs we have now, or the alcoholism.”
—Spike Lee (b. 1956)