Opioid and Dopamine Systems in Pain and Pleasure
The neural systems to be explored when trying to for a neurochemical relationship between pain and pleasure are the opioid and dopamine systems. The opioid system is responsible for the actual experience of the sensation, whereas the dopamine system is responsible for the anticipation or expectation of the experience. Opioids work in the modulation of pleasure or pain relief by either blocking neurotransmitter release or by hyperpolarizing neurons by opening up a potassium channel which effectively temporarily blocks the neuron.
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Famous quotes containing the words systems, pain and/or pleasure:
“The only people who treasure systems are those whom the whole truth evades, who want to catch it by the tail. A system is just like truth’s tail, but the truth is like a lizard. It will leave the tail in your hand and escape; it knows that it will soon grow another tail.”
—Ivan Sergeevich Turgenev (1818–1883)
“In the small circle of pain within the skull
You still shall tramp and tread one endless round
Of thought, to justify your action to yourselves,
Weaving a fiction which unravels as you weave,
Pacing forever in the hell of make-believe
Which never is belief: this is your fate on earth
And we must think no further of you.”
—T.S. (Thomas Stearns)
“There is no Pleasure like that of receiving Praise from the Praiseworthy.”
—Richard Steele (1672–1729)