FR/Fd/P450 Systems
Mitochondrial and some bacterial P450 systems employ soluble Fe2S2 ferredoxins (Fd) that act as single electron carriers between FAD-containing ferredoxin reductase (FR) and P450. In mitochondrial monooxygenase systems, adrenodoxin functions as a soluble electron carrier between NADPH:adrenodoxin reductase and several membrane-bound P450s (CYP11A, CYP11B, CYP27). In bacteria, putidaredoxin, terpredoxin, and rhodocoxin serve as electron carriers between corresponding NADH-dependent ferredoxin reductases and soluble P450s (CYP101, CYP108, CYP116).
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O2 |
| NADH |
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O2 |
| NADH |
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O2 |
The general scheme of electron flow in the P450 systems containing adrenodoxin-type ferredoxins is:
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Read more about this topic: P450-containing Systems
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“Our little systems have their day;
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