FR/Fd/P450 Systems
Mitochondrial and some bacterial P450 systems employ soluble Fe2S2 ferredoxins (Fd) that act as single electron carriers between FAD-containing ferredoxin reductase (FR) and P450. In mitochondrial monooxygenase systems, adrenodoxin functions as a soluble electron carrier between NADPH:adrenodoxin reductase and several membrane-bound P450s (CYP11A, CYP11B, CYP27). In bacteria, putidaredoxin, terpredoxin, and rhodocoxin serve as electron carriers between corresponding NADH-dependent ferredoxin reductases and soluble P450s (CYP101, CYP108, CYP116).
| NADH |
|
|
|
|
|
|
|
O2 |
| NADH |
|
|
|
|
|
|
|
O2 |
| NADH |
|
|
|
|
|
|
|
O2 |
The general scheme of electron flow in the P450 systems containing adrenodoxin-type ferredoxins is:
| NAD(P)H |
|
|
|
|
|
|
|
O2 |
Read more about this topic: P450-containing Systems
Famous quotes containing the word systems:
“We have done scant justice to the reasonableness of cannibalism. There are in fact so many and such excellent motives possible to it that mankind has never been able to fit all of them into one universal scheme, and has accordingly contrived various diverse and contradictory systems the better to display its virtues.”
—Ruth Benedict (1887–1948)