FMN/Fd/P450 Systems
An unusual one-component P450 system was originally found in Rhodococcus sp. NCIMB 9784 (CYP116B2). In this system, the N-terminal P450 domain is fused to the reductase domain that shows sequence similarity to phthalate dioxygenase reductase and consists, in its turn, of FMN-binding domain and C-terminal plant-type ferredoxin domain. Similar systems have been identified in the heavy-metal-tolerant bacterium Ralstonia metallidurans (CYP116A1) and in several species of Burkolderia. The general scheme of electron flow in this system appears to be:
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