Oxidation of Secondary Alcohols To Ketones - Swern Oxidation

Swern Oxidation

Swern oxidation oxidises secondary alcohols into ketones using oxalyl chloride and dimethylsulfoxide. It also requires an organic base, such as triethylamine.

The by-products are dimethyl sulfide (Me2S), carbon monoxide (CO), carbon dioxide (CO2) and – when triethylamine is used as base – triethylammonium chloride (C6H15NHCl). Dimethyl sulfide and carbon monoxide are very toxic and volatile compounds, so the reaction and the work-up needs to be performed in a fume cupboard.

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