Oxalosuccinic acid is a substrate of the citric acid cycle. It is acted upon by isocitrate dehydrogenase. Salts and esters of oxalosuccinic acid are known as oxalosuccinates.
Oxalosuccinic acid/Oxalosuccinate is an unstable 6-Carbon intermediate in the TriCarboxylic Acid Cycle. It's an alpha-keto compound, formed during the oxidative decarboxylation of isocitrate to Alpha-Ketoglutarate, which is catalyzed by the enzyme Isocitrate Dehydrogenase. Oxalosuccinate never leaves the active site of the enzyme, however it's unstable and immediately undergoes decarboxylation to produce the 5-carbon compound, Alpha-Ketoglutarate.
| Citric Acid Cycle Metabolic Pathway | ||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Oxaloacetate | Malate | Fumarate | Succinate | Succinyl-CoA | ||||||||||||||||||
| Acetyl-CoA | NADH + H+ | NAD+ | H2O | FADH2 | FAD | CoA + ATP(GTP) | Pi + ADP(GDP) | |||||||||||||||
| + | H2O | NADH + H+ + CO2 | ||||||||||||||||||||
| CoA | NAD+ | |||||||||||||||||||||
| H2O | H2O | NAD(P)+ | NAD(P)H + H+ | CO2 | ||||||||||||||||||
| Citrate | cis-Aconitate | Isocitrate | Oxalosuccinate | α-Ketoglutarate | ||||||||||||||||||
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