Function
This four-carbon dicarboxylic acid is a protonated variant of oxaloacetate, which is an intermediate of the citric acid cycle and gluconeogenesis. Oxaloacetate forms upon oxidation of L-malate, catalysed by malate dehydrogenase, and reacts with Acetyl-CoA to form citrate, catalysed by citrate synthase. It also forms in the mesophyll of plants by the condensation of CO2 with phosphoenolpyruvate, catalysed by PEP Carboxykinase. It can arise from pyruvate via an anaplerotic reaction. Oxaloacetate is also a potent inhibitor of Complex II.
Read more about this topic: Oxaloacetic Acid
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