In enzymology, an oxalate-CoA ligase (EC 6.2.1.8) is an enzyme that catalyzes the chemical reaction
- ATP + oxalate + CoA AMP + diphosphate + oxalyl-CoA
The 3 substrates of this enzyme are ATP, oxalate, and CoA, whereas its 3 products are AMP, diphosphate, and oxalyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is oxalate:CoA ligase (AMP-forming). Other names in common use include oxalyl-CoA synthetase, and oxalyl coenzyme A synthetase. This enzyme participates in glyoxylate and dicarboxylate metabolism.