Other Red Cell Antigens - Other High-incidence Antigens

Other High-incidence Antigens

These antigens are almost universally present on human red cells, but their absence has been noted in some individuals and some have been associated with transfusion reactions or other problems. Finding compatible units for transfusion to a patient that lacks one of these antigens is a major challenge and some countries maintain rare donor registries specifically for that purpose.

• Lan antigen: anti-Lan is IgG and has been associated with transfusion reactions. A weaker variant of the antigen has also been reported.
• Ata Antigen: only found in people of African descent. Associated with hemolytic transfusion reactions but not hemolytic disease of the newborn.
• Jra Antigen: mostly found in Japan. Not associated with acute transfusion reactions.
• AnWj Antigen: the receptor for Haemophilus influenzae. Implicated in severe hemolytic transfusion reactions.
• Sda Antigen: This antigen is present on cells other than red cells and is less frequent but still very common. It may be associated with transfusion reactions, but not hemolytic disease of the newborn.