Otani may refer to:
- Ōtani Kōzui (1876—1948), a Japanese explorer of Central Asia.
- Otani University
- Otani-ha, a branch of the Jodo Shinshu Buddhist tradition.
- The House of Otani, family name of the descendants of Shinran - founder of Jodo Shinshu.
- New Otani Art Museum
- Shinjiro Otani, pro wrestler
- Kow Otani, Japanese composer