Osmosis Jones is a 2001 live-action/animated comedy film directed by Tom Sito and Piet Kroon for the animated segments and the Farrelly brothers for the live-action ones. Unusual in this genre, the animated characters are inside the live-action ones.
It is set in a fictionalized version of the human body, where micro-organisms or any being based in ones are anthropomorphic and centers on Frank Detorre, a slovenly zookeeper. Osmosis Jones, a white blood cell teams up with Drix, a cold pill, against Thrax, a deadly virus, who plans to kill Frank within a matter of hours and other characters living within him.
It met with mixed reviews, and was not a success at the box office, earning under $14 million against a budget of $70 million. Despite the lack of accolades, the film sold well in home media. It spawned a Saturday morning cartoon television show, Ozzy & Drix, which aired on Kids WB from 2002 to 2004, albeit being completely animated and more emphasis on Osmosis and Drix's partnership in a different body. Limited merchandise was created due to the film's financial failure.
Read more about Osmosis Jones: Plot, Production, Footage Cut From The Final Film, Merchandising, Soundtrack, MPAA Issue
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