OS9 (gene)

Identifiers Symbols OS9; ERLEC2; OS-9 External IDs OMIM: 609677 MGI: 1924301 HomoloGene: 31409 GeneCards: OS9 Gene

Gene Ontology
Molecular function	• glycoprotein binding • protease binding • protein binding
Cellular component	• Hrd1p ubiquitin ligase complex • endoplasmic reticulum lumen
Biological process	• protein targeting • protein retention in ER lumen • protein ubiquitination • ER-associated protein catabolic process • response to endoplasmic reticulum stress • protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 10956 216440 Ensembl ENSG00000135506 ENSMUSG00000040462 UniProt Q13438 Q8K2C7 RefSeq (mRNA) NM_001017956 NM_001171026 RefSeq (protein) NP_001017956 NP_001164497 Location (UCSC) Chr 12:
58.09 – 58.12 Mb Chr 10:
127.09 – 127.12 Mb PubMed search

Protein OS-9 is a protein that in humans is encoded by the OS9 gene.

This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.