Orsino may refer to:
- Orsino, Florida, United States
- Orsino (novel), a novel by Romain Rolland
- Orsino (Twelfth Night), a character in the Shakespearean comedy Twelfth Night
- Orsino is the name of an elven mage in Dragon Age 2
People with the surname Orsino:
- John Orsino (born 1938), former Major League Baseball catcher
- Philip Orsino (born 1954), Canadian businessman