Ornithine Transcarbamylase

Ornithine Transcarbamylase

Identifiers Symbols OTC; OCTD External IDs OMIM: 300461 MGI: 97448 HomoloGene: 446 ChEMBL: 2222 GeneCards: OTC Gene EC number 2.1.3.3

Gene Ontology
Molecular function	• ornithine carbamoyltransferase activity • phospholipid binding • amino acid binding • phosphate ion binding
Cellular component	• mitochondrion • mitochondrial inner membrane • mitochondrial matrix • ornithine carbamoyltransferase complex
Biological process	• urea cycle • liver development • arginine biosynthetic process • midgut development • response to zinc ion • citrulline biosynthetic process • response to insulin stimulus • cellular nitrogen compound metabolic process • response to drug • small molecule metabolic process • anion homeostasis • protein homotrimerization • response to biotin
Sources: Amigo / QuickGO

RNA expression pattern More reference expression data Orthologs Species Human Mouse Entrez 5009 18416 Ensembl ENSG00000036473 ENSMUSG00000031173 UniProt P00480 P11725 RefSeq (mRNA) NM_000531.5 NM_008769.3 RefSeq (protein) NP_000522.3 NP_032795.1 Location (UCSC) Chr X:
38.21 – 38.28 Mb Chr X:
10.25 – 10.32 Mb PubMed search

Ornithine transcarbamoylase (OTC) (also called ornithine carbamoyltransferase) is an enzyme that catalyzes the reaction between carbamoyl phosphate (CP) and ornithine (Orn) to form citrulline (Cit) and phosphate (P_i). In plants and microbes, OTC is involved in arginine (Arg) biosynthesis, whereas in mammals it is located in the mitochondria and is part of the urea cycle.