Methods For Preparation of C-F Bonds
Organofluorine compounds are prepared by numerous routes, depending on the degree and regiochemistry of fluorination sought and the nature of the precursors. The direct fluorination of hydrocarbons with F2, often diluted with N2, is useful for highly fluorinated compounds:
- R3CH + F2 → R3CF + HF
Such reactions however are often unselective and require care because hydrocarbons can uncontrollably "burn" in F2, analogous to the combustion of hydrocarbon in O2. For this reason, alternative fluorination methodologies have been developed. Generally, such methods are classified into two classes.
Read more about this topic: Organofluorine Chemistry
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