ORF, or Orf may refer to:
- Orf (disease), a cutaneous condition
- ORF (broadcaster), the Austrian public service broadcaster
- Open reading frame, a portion of the genome
- Norfolk International Airport, IATA airport code ORF
- ORF format, Olympus raw image file format with extension .orf
- Observer Research Foundation, an Indian research institute
- Open Road Films, a joint venture of Regal Entertainment Group and AMC Theatres