Pathophysiology
Physiologically, antibodies to thyroid peroxidase and/or thyroglobulin cause gradual destruction of follicles in the thyroid gland. Accordingly, the disease can be detected clinically by looking for these antibodies in the blood. It is also characterised by invasion of the thyroid tissue by leukocytes, chiefly T-lymphocytes.
Ord's thyroiditis usually results in hypothyroidism. Transient hyperthyroid states in the acute phase, a common observation in Hashimoto's thyroiditis, are rare in Ord's disease.
Read more about this topic: Ord's Thyroiditis