Treatment
There is no known definitive cure for OMS. However, several drugs have proven to be effective in its treatment.
Some of medication used to treat the symptoms are:
- ACTH has shown improvements in symptoms but can result in an incomplete recovery with residual deficits.
- Corticosteroids (such as prednisone or methylprednisolone) used at high dosages (500 mg - 2 g per day intravenously for a course of 3 to 5 days) can accelerate regression of symptoms. Subsequent very gradual tapering with pills generally follows. Most patients require high doses for months to years before tapering.
- Intravenous Immunoglobulins (IVIg) are often used with varying results.
- Several other immunosuppressive drugs, such as cyclophosphamide and azathioprine, may be helpful in some cases.
- Chemotherapy for neuroblastoma may be effective, although data is contradictory and unconvincing at this point in time.
- Rituximab has been used with encouraging results.
- Other medications are used to treat symptoms without influencing the nature of the disease (symptomatic treatment):
- Trazodone can be useful against irritability and sleep problems
- Additional treatment options include plasmapheresis for severe, steroid-unresponsive relapses.
A more detailed summary of current treatment options can be found at Treatment Options
The following medications should probably be avoided:
- Midazolam - Can cause irritability.
- Melatonin - Is known to stimulate the immune system.
- Also, see "An Innovative Approach to the Problem of Sedating Children with Opsoclonus-Myoclonus Syndrome". Pranzatelli Abstracts. http://www.omsusa.org/pranzatelli-abstracts.htm. for more details
Read more about this topic: Opsoclonus Myoclonus Syndrome
Famous quotes containing the word treatment:
“If the study of all these sciences, which we have enumerated, should ever bring us to their mutual association and relationship, and teach us the nature of the ties which bind them together, I believe that the diligent treatment of them will forward the objects which we have in view, and that the labor, which otherwise would be fruitless, will be well bestowed.”
—Plato (c. 427–347 B.C.)
“A regular council was held with the Indians, who had come in on their ponies, and speeches were made on both sides through an interpreter, quite in the described mode,—the Indians, as usual, having the advantage in point of truth and earnestness, and therefore of eloquence. The most prominent chief was named Little Crow. They were quite dissatisfied with the white man’s treatment of them, and probably have reason to be so.”
—Henry David Thoreau (1817–1862)
“Judge Ginsburg’s selection should be a model—chosen on merit and not ideology, despite some naysaying, with little advance publicity. Her treatment could begin to overturn a terrible precedent: that is, that the most terrifying sentence among the accomplished in America has become, “Honey—the White House is on the phone.””
—Anna Quindlen (b. 1952)