Treatment
There is no known definitive cure for OMS. However, several drugs have proven to be effective in its treatment.
Some of medication used to treat the symptoms are:
- ACTH has shown improvements in symptoms but can result in an incomplete recovery with residual deficits.
- Corticosteroids (such as prednisone or methylprednisolone) used at high dosages (500 mg - 2 g per day intravenously for a course of 3 to 5 days) can accelerate regression of symptoms. Subsequent very gradual tapering with pills generally follows. Most patients require high doses for months to years before tapering.
- Intravenous Immunoglobulins (IVIg) are often used with varying results.
- Several other immunosuppressive drugs, such as cyclophosphamide and azathioprine, may be helpful in some cases.
- Chemotherapy for neuroblastoma may be effective, although data is contradictory and unconvincing at this point in time.
- Rituximab has been used with encouraging results.
- Other medications are used to treat symptoms without influencing the nature of the disease (symptomatic treatment):
- Trazodone can be useful against irritability and sleep problems
- Additional treatment options include plasmapheresis for severe, steroid-unresponsive relapses.
A more detailed summary of current treatment options can be found at Treatment Options
The following medications should probably be avoided:
- Midazolam - Can cause irritability.
- Melatonin - Is known to stimulate the immune system.
- Also, see "An Innovative Approach to the Problem of Sedating Children with Opsoclonus-Myoclonus Syndrome". Pranzatelli Abstracts. http://www.omsusa.org/pranzatelli-abstracts.htm. for more details
Read more about this topic: Opsoclonus Myoclonus Syndrome
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