In molecular genetics, an open reading frame (ORF) is the part of a reading frame that contains no stop codons. The transcription termination pause site is located after the ORF, beyond the translation stop codon, because if transcription were to cease before the stop codon, an incomplete protein would be made during translation.
Normally, inserts which interrupt the reading frame of a subsequent region after the start codon cause frameshift mutation of the sequence and dislocate the sequences for stop codons.
Read more about Open Reading Frame: Significance, Example
Famous quotes containing the words open, reading and/or frame:
“I am Black because I come from the earth’s inside
now take my word for jewel in the open light.”
—Audre Lorde (b. 1934)
“A society person who is enthusiastic about modern painting or Truman Capote is already half a traitor to his class. It is middle-class people who, quite mistakenly, imagine that a lively pursuit of the latest in reading and painting will advance their status in the world.”
—Mary McCarthy (1912–1989)
“A cold and searching wind drives away all contagion, and nothing can withstand it but what has a virtue in it, and accordingly, whatever we meet with in cold and bleak places, as the tops of mountains, we respect for a sort of sturdy innocence, a Puritan toughness. All things beside seem to be called in for shelter, and what stays out must be part of the original frame of the universe, and of such valor as God himself.”
—Henry David Thoreau (1817–1862)