In molecular genetics, an open reading frame (ORF) is the part of a reading frame that contains no stop codons. The transcription termination pause site is located after the ORF, beyond the translation stop codon, because if transcription were to cease before the stop codon, an incomplete protein would be made during translation.
Normally, inserts which interrupt the reading frame of a subsequent region after the start codon cause frameshift mutation of the sequence and dislocate the sequences for stop codons.
Read more about Open Reading Frame: Significance, Example
Famous quotes containing the words open, reading and/or frame:
“It’s fairly obvious that American education is a cultural flop. Americans are not a well-educated people culturally, and their vocational education often has to be learned all over again after they leave school and college. On the other hand, they have open quick minds and if their education has little sharp positive value, it has not the stultifying effects of a more rigid training.”
—Raymond Chandler (1888–1959)
“After which you led me to water
And bade me drink, which I did, owing to your kindness.
You would not let me out for two days and three nights,
Bringing me books bound in wild thyme and scented wild grasses
As if reading had any interest for me ...”
—John Ashbery (b. 1927)
“I can imagine no more comfortable frame of mind for the conduct of life than a humorous resignation.”
—W. Somerset Maugham (1874–1966)