In molecular genetics, an open reading frame (ORF) is the part of a reading frame that contains no stop codons. The transcription termination pause site is located after the ORF, beyond the translation stop codon, because if transcription were to cease before the stop codon, an incomplete protein would be made during translation.
Normally, inserts which interrupt the reading frame of a subsequent region after the start codon cause frameshift mutation of the sequence and dislocate the sequences for stop codons.
Read more about Open Reading Frame: Significance, Example
Famous quotes containing the words open, reading and/or frame:
“The young women, what can they not learn, what can they not achieve, with Columbia University annex thrown open to them? In this great outlook for women’s broader intellectual development I see the great sunburst of the future.”
—M. E. W. Sherwood (1826–1903)
“The reading public is intellectually adolescent at best, and it is obvious that what is called “significant literature” will only be sold to this public by exactly the same methods as are used to sell it toothpaste, cathartics and automobiles.”
—Raymond Chandler (1888–1959)
“I frame no hypotheses; for whatever is not deduced from the phenomena is to be called a hypothesis; and hypotheses, whether metaphysical or physical, whether of occult qualities or mechanical, have no place in experimental philosophy.”
—Isaac Newton (1642–1727)