Involvement of Onuf's Nucleus in Shy-Drager Syndrome
In order to study Onuf’s nucleus from the opposite perspective (meaning cases where it was not preserved) studies were done on Shy-Drager syndrome. Shy-Drager syndrome is a rare neurodegenerative disease that attacks the autonomic nervous system. Since the main symptom of Shy-Drager syndrome is incontinence it makes it a good candidate to study its effects on Onuf’s nucleus. When the sacral sections of the spinal cord were studied in patients with Shy-Drager syndrome, it was revealed that cell death was confined to the area of Onuf’s nucleus. This, once again, verified the role Onuf’s nucleus in vesicorectal function.
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