Involvement of Onuf's Nucleus in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis is a disease that causes degeneration of motoneurons that control voluntary muscle movement. Surprisingly, the bladder and rectum sphincters remain normal even during the final terminal stages of the illness. Since these muscles are controlled by Onuf’s nucleus, it is of great importance in the study of this disease. In amyotrophic lateral sclerosis, Onuf’s nucleus is preserved but the other anterior horn cell groups atrophy. This discovery reinforced the notion that Onuf’s nucleus controlled the muscles related to sphincter function in the anus and urethra.
In a study conducted by Kihira et al., eight individuals with amyotrophic lateral sclerosis were compared to nine control cases. The results indicated that the total number of neurons in Onuf’s nucleus in patients with amyotrophic lateral sclerosis did not differ from the control patients. However, normal neurons decreased in number while atrophic neurons increased. It was also shown that the decrease in the number of normal neurons was not due to aging. Patients with amyotrophic lateral sclerosis also contain less RNA in their motoneurons than normal individuals. The decrease in RNA is correlated with the decrease in size of the nucleolus. Thus, the size of the nucleolus may be an early indicator of amyotrophic lateral sclerosis.
There is often sparing of Onuf's nucleus in Werdnig-Hoffmann disease (spinal muscular atrophy type 1).
Read more about this topic: Onuf's Nucleus
Famous quotes containing the words involvement and/or nucleus:
“Even if you find yourself in a heated exchange with your toddler, it is better for your child to feel the heat rather than for him to feel you withdraw emotionally.... Active and emotional involvement between parent and child helps the child make the limits a part of himself.”
—Stanley I. Greenspan (20th century)
“I could not undertake to form a nucleus of an institution for the development of infant minds, where none already existed. It would be too cruel.”
—Henry David Thoreau (1817–1862)