O-pyrocatechuate Decarboxylase

In enzymology, an o-pyrocatechuate decarboxylase (EC 4.1.1.46) is an enzyme that catalyzes the chemical reaction

2,3-dihydroxybenzoate catechol + CO₂

Hence, this enzyme has one substrate, 2,3-dihydroxybenzoate, and two products, catechol and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 2,3-dihydroxybenzoate carboxy-lyase (catechol-forming). This enzyme is also called 2,3-dihydroxybenzoate carboxy-lyase. This enzyme participates in benzoate degradation via hydroxylation and carbazole degradation.