Role in Cancer and Tumorigenesis
In several types of cancer, a loss of Numb expression has been demonstrated. This is well-established in breast cancer, where a loss of Numb correlates with a worse prognosis. Numb loss has also been demonstrated in Non-small-cell lung carcinoma, salivary gland carcinoma, and chronic myelogenous leukemia. Restoration of Numb function, or manipulation of enzymes in the ubiquitin mechanism, are some possible research directions for the treatment of certain cancer types.
Read more about this topic: NUMB (gene)
Famous quotes containing the words role in, role and/or cancer:
“Language makes it possible for a child to incorporate his parents’ verbal prohibitions, to make them part of himself....We don’t speak of a conscience yet in the child who is just acquiring language, but we can see very clearly how language plays an indispensable role in the formation of conscience. In fact, the moral achievement of man, the whole complex of factors that go into the organization of conscience is very largely based upon language.”
—Selma H. Fraiberg (20th century)
“The real test of a man is not how well he plays the role he has invented for himself, but how well he plays the role that destiny assigned to him.”
—Jan Patocka (1907–1977)
“I’m beginning to believe that Killer Illiteracy ought to rank near heart disease and cancer as one of the leading causes of death among Americans. What you don’t know can indeed hurt you, and so those who can neither read nor write lead miserable lives, like Richard Wright’s character, Bigger Thomas, born dead with no past or future.”
—Ishmael Reed (b. 1938)