Role in Cancer and Tumorigenesis
In several types of cancer, a loss of Numb expression has been demonstrated. This is well-established in breast cancer, where a loss of Numb correlates with a worse prognosis. Numb loss has also been demonstrated in Non-small-cell lung carcinoma, salivary gland carcinoma, and chronic myelogenous leukemia. Restoration of Numb function, or manipulation of enzymes in the ubiquitin mechanism, are some possible research directions for the treatment of certain cancer types.
Read more about this topic: NUMB (gene)
Famous quotes containing the words role and/or cancer:
“Our role is to support anything positive in black life and destroy anything negative that touches it. You have no other reason for being. I don’t understand art for art’s sake. Art is the guts of the people.”
—Elma Lewis (b. 1921)
“The same people who tell us that smoking doesn’t cause cancer are now telling us that advertising cigarettes doesn’t cause smoking.”
—Ellen Goodman (b. 1941)