Nucleoporin 62

Nucleoporin 62

Identifiers Symbols NUP62; IBSN; SNDI; p62 External IDs OMIM: 605815 MGI: 1351500 HomoloGene: 68773 GeneCards: NUP62 Gene

Gene Ontology
Molecular function	• chromatin binding • nucleocytoplasmic transporter activity • protein binding • structural constituent of nuclear pore • receptor signaling complex scaffold activity • SH2 domain binding • ubiquitin binding • thyroid hormone receptor binding
Cellular component	• spindle pole • nuclear envelope • nuclear pore • cytoplasm • ribonucleoprotein complex • nucleocytoplasmic shuttling complex • nuclear membrane • intracellular membrane-bounded organelle • pore complex
Biological process	• carbohydrate metabolic process • transcription, DNA-dependent • nucleocytoplasmic transport • cell surface receptor signaling pathway • cell death • negative regulation of cell proliferation • hexose transport • hormone-mediated signaling pathway • regulation of signal transduction • regulation of glucose transport • protein transport • glucose transport • viral reproduction • cytokine-mediated signaling pathway • viral reproductive process • negative regulation of apoptotic process • negative regulation of programmed cell death • positive regulation of I-kappaB kinase/NF-kappaB cascade • small molecule metabolic process • positive regulation of epidermal growth factor receptor signaling pathway • positive regulation of transcription, DNA-dependent • regulation of Ras protein signal transduction • mRNA transport • transmembrane transport
Sources: Amigo / QuickGO

Orthologs Species Human Mouse Entrez 23636 18226 Ensembl ENSG00000213024 ENSMUSG00000043858 UniProt P37198 Q63850 RefSeq (mRNA) NM_001193357 NM_053074 RefSeq (protein) NP_001180286 NP_444304 Location (UCSC) Chr 19:
50.41 – 50.43 Mb Chr 7:
44.82 – 44.83 Mb PubMed search

Nucleoporin p62 (p62) is a protein complex associated with the nuclear envelope. The p62 protein remains associated with the nuclear pore complex-lamina fraction. p62 is synthesized as a soluble cytoplasmic precursor of 61 kDa followed by modification that involve addition of N-acetylglucosamine residues. followed by association with other complex proteins.

The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.