Reactions
- Conjugated carbonyls react with secondary amines to form 1,4-keto-amines. For example the conjugate addition of methylamine to 2-cyclohexenone gives the compound 3-(N-methylamino)-cyclohexanone.
- Conjugated carbonyls react with hydrogen cyanide to 1,4-keto-nitriles. See hydrocyanation of unsaturated carbonyls. In the Nagata reaction the cyanide source is diethylaluminum cyanide.
- The Gilman reagent is an effective nucleophile for 1,4-additions to conjugated carbonyls...
- The Michael reaction involves conjugate additions of enolates to conjugated carbonyls.
- The Stork enamine reaction involves the conjugate addition of enamines to conjugated carbonyls.
Read more about this topic: Nucleophilic Conjugate Addition
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