Reactions
- Conjugated carbonyls react with secondary amines to form 1,4-keto-amines. For example the conjugate addition of methylamine to 2-cyclohexenone gives the compound 3-(N-methylamino)-cyclohexanone.
- Conjugated carbonyls react with hydrogen cyanide to 1,4-keto-nitriles. See hydrocyanation of unsaturated carbonyls. In the Nagata reaction the cyanide source is diethylaluminum cyanide.
- The Gilman reagent is an effective nucleophile for 1,4-additions to conjugated carbonyls...
- The Michael reaction involves conjugate additions of enolates to conjugated carbonyls.
- The Stork enamine reaction involves the conjugate addition of enamines to conjugated carbonyls.
Read more about this topic: Nucleophilic Conjugate Addition
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“Cuteness in children is totally an adult perspective. The children themselves are unaware that the quality exists, let alone its desirability, until the reactions of grownups inform them.”
—Leontine Young (20th century)
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—George Orwell (1903–1950)
“Separation anxiety is normal part of development, but individual reactions are partly explained by experience, that is, by how frequently children have been left in the care of others.... A mother who is never apart from her young child may be saying to him or her subliminally: “You are only safe when I’m with you.””
—Cathy Rindner Tempelsman (20th century)